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IL-13 Levels Correlate With AD Severity

Expression levels of IL-13 in lesional skin were correlated with disease severity.1,2

IL-13 mRNA Expression in Lesional Skin Correlates With SCORAD

mRNA expression levels of IL-13 in lesional skin were correlated with disease severity, as measured by SCORing Atopic Dermatitis (SCORAD)1

Chart created by ADKeySuspect.com showing IL-13 mRNA expression in lesional skin and correlation with SCORAD

CPM, counts per million; SCORAD, Scoring Atopic Dermatitis.

IL-13 Protein Levels in Lesional Skin
Correlate With Objective SCORAD*

  • Based on IL-13 protein levels in skin-derived interstitial fluid (ISF), a strong correlation with disease severity as measured by objective SCORAD was established

Chart created by ADKeySuspect.com showing IL-13 protein levels in lesional skin and correlation with Objective SCORAD

*Objective SCORAD does not include the subjective items daily pruritus and sleeplessness.

Overall, the growing body of evidence supporting the relative overexpression of IL-13 in lesional skin suggests that AD is driven by IL-131-3

Latest Educational Resources for Atopic Dermatitis

The Clinicians' Corner provides resources to help better understand the developing field of AD, as well as to better serve patients.

SEE RESOURCES

  1. Tsoi LC, Rodriguez E, Degenhardt F, et al. Atopic dermatitis is an IL-13-dominant disease with greater molecular heterogeneity compared to psoriasis. J Invest Dermatol. 2019;139(7):1480-1489.
  2. Szegedi K, Lutter R, Res PC, et al. Cytokine profiles in interstitial fluid from chronic atopic dermatitis skin. J Eur Acad Dermatol Venereol. 2015;29(11):2136-2144.
  3. Koppes SA, Brans R, Ljubojevic Hadzavdic S, Frings-Dresen MH, Rustemeyer T, Kezic S. Stratum corneum tape stripping: monitoring of inflammatory mediators in atopic dermatitis patients using topical therapy. Int Arch Allergy Immunol. 2016;170(3):187-193.