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Unpredictability of Atopic Dermatitis

Atopic dermatitis is an unpredictable, complex disease that can manifest differently in each patient, and there’s a large unmet need for long-term disease control.1,2

Atopic dermatitis is an unpredictable, complex disease with varying1:

  • Degrees of severity
  • Skin involvement
  • Frequency of flares

Atopic dermatitis is a chronic, lifelong affliction

graphic created by to show atopic dermatitis disease unpredictablity

of childhood atopic dermatitis persists into adulthood3-6

Patients live in fear of the next flare

graphic created by to show atopic dermatitis disease unpredictablity

of patients are either always or sometimes worried about when their atopic dermatitis is going to flare next6

Despite advancements, more management options are needed2,7

Understanding the difficulties that patients face is just one part of tackling this debilitating disease. Atopic dermatitis has a complex pathophysiology that drives the visible signs, symptoms, and underlying inflammation.8-10

  1. Silverberg JI, Gelfand JM, Margolis DJ, et al. Patient burden and quality of life in atopic dermatitis in US adults: a population-based cross-sectional study. Ann Allergy Asthma Immunol. 2018;121(3):340-347.
  2. Renert-Yuval Y, Guttman-Yassky E. New treatments for atopic dermatitis targeting beyond IL-4/IL-13 cytokines. Ann Allergy Asthma Immunol. 2020;124:28-35.
  3. Abuabara K, Margolis DJ, Langan SM. The long-term course of atopic dermatitis. Dermatol Clin. 2017;35(3):291-297.
  4. Tsai TF, Rajagopalan M, Chu CY, et al. Burden of atopic dermatitis in Asia. J Dermatol. 2019;46(10):825-834.
  5. Reed B, Blaiss MS. The burden of atopic dermatitis. Allergy Asthma Proc. 2018;39(6):406-410.
  6. Zuberbier T, Orlow SJ, Paller AS, et al. Patient perspectives on the management of atopic dermatitis. J Allergy Clin Immunol. 2006;118(1):226-232.
  7. Weidinger S, Novak N. Lancet. 2016;387:1109-1122.
  8. Jakasa I, Verberk MM, Esposito M, Bos JD, Kezic S. Altered penetration of polyethylene glycols into uninvolved skin of atopic dermatitis patients. J Invest Dermatol. 2007;127(1):129-134.
  9. May RD, Fung M. Strategies targeting the IL-4/IL-13 axes in disease. Cytokine. 2015;75(1):89-116.
  10. Williams MR, Gallo RL. The role of the skin microbiome in atopic dermatitis. Curr Allergy Asthma Rep. 2015;15(65):1-10.