Inflammation in AD Skin Is Driven by an Outside-In/Inside-Out Process
- Immune dysregulation involves the activation of type 2 T-helper (Th2) cells and subsequent inflammatory signaling2
- Skin-barrier dysfunction results in inflammatory signaling due to antigen penetration of AD skin2
- Resulting chronic inflammation further contributes to both skin-barrier dysfunction and immune dysregulation2
![Graphic created by ADKeySuspect.com representing chronic inflammation in patients with skin-barrier dysfunction vs immune dysregulation.](https://mc-df05ef79-e68e-4c65-8ea2-953494-cdn-endpoint.azureedge.net/-/media/gdm/adkeysuspect/image-package/skin-barrier-vs-immune-dysregulation-small.png?la=en-us&revision=9c5f487f-3c50-4d09-b747-90154713ef64&h=410&w=1000&rev=987ef69d0dc64998bacd03a246761a01&hash=D689CCFCFD945913FD3070F7226751D5)